Cholestasic Hepatitis secondary to Neonatal Infection by Cytomegalovirus: Case Report

Abstract

Cytomegalovirus (CMV) belonging to the family herpes viridae; occurs in different areas without specific predisposing factors. Worldwide it has an incidence rate of 0.6-0.7% among all births. The mortality of symptomatic
congenital infection by Cytomegalovirus can reach up to 4%. Liver involvement with the Cytomegalovirus virus can be considered as multiple systemic damage or as isolated liver damage, such as neonatal hepatitis or cholestasis. Primary CMV infection is usually asymptomatic, then establishes itself as a latent infection in polymorphonuclear cells, T lymphocytes, vascular endothelial tissue, renal epithelial cells and salivary cells. We did a case study of a 5-month-old infant with jaundice, acolia and coluria secondary to cytomegalovirus infection, presenting as a cholestatic syndrome diagnosed by IgG (1,492mg / dl), IgM (152,6mg / dl) positive for cytomegalovirus. There is very little information in the medical literature about the clinical manifestations of cytomegalovirus infection in childhood.