Carotid body tumor: a literature review
Main Article Content
Keywords
carotid body, endarterectomy, paraganglioma
Abstract
Carotid body tumor is a paraganglioma located at the carotid bifurcation and originates from chemoreceptor cells at the neck level. Although its incidence is low, it is the main paraganglioma at the head and neck level. They are usually benign; however, a malignancy rate of 5-10 % has been reported. They frequently present as asymptomatic masses at the anterior level of the sternocleidomastoid muscle. Occasionally they can cause nerve compression of various cranial nerves and symptoms of adrenergic discharge due to the release of catecholamines. Diagnosis is made through Doppler ultrasound, computed tomography angiography or magnetic resonance imaging. The treatment of choice is surgical resection by endarterectomy. Among the most frequent surgical complications are cerebrovascular events and cranial nerve damage. This literature review addresses the clinical presentation and therapeutic management of carotid body tumor in a comprehensive and up-to-date manner.
References
2. Molina ME, Carrillo I., Arroyo VA, Gómez O, Herráinz R, Vaquero C, et al. Carotid glomus in childhood: presentation of a clinical case. Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica. 2020 Oct;34(2):90–4.
3. Kaygusuz I, Karlidag T, Keles E, Yalcin S, Yüksel K. Carotid Body Tumor. Journal of Craniofacial Surgery. 2015 Oct;26(7):e586–9.
4. Jeevan DS, Saleh M, LaBagnara M, Neil JA, Hillard VH. Malignant carotid body tumor presenting with myelopathy: case report. Journal of Neurosurgery: Spine. 2016 Apr;24(4):660–3.
5. Illuminati G, Pasqua R, Nardi P, Fratini C, Minni A, Calio’ FG. Results of resection of carotid body tumors with and without lymphnodes’ dissection. Surgical Oncology. 2021 Jun;37:101555.
6. Hoang VT, Trinh CT, Lai TAK, Doan DT, Tran TTT. Carotid body tumor: a case report and literature review. Journal of Radiology Case Reports. 2019 Aug 31;13(8).
7. Athanasiou A, Liappis CD, Rapidis AD, Fassolis A, Stavrianos SD, Kokkalis G. Carotid Body Tumor: Review of the Literature and Report of a Case With a Rare Sensorineural Symptomatology. Journal of Oral and Maxillofacial Surgery. 2007 Jul;65(7):1388–93.
8. Patlola R, Ingraldi A, Walker C, Allie D, Khan IA. Carotid body tumor. International Journal of Cardiology. 2010 Aug;143(1):e7–10.
9. Naughton J, Morley E, Chan D, Fong Y, Bosanquet D, Lewis M. Carotid body tumours. British Journal of Hospital Medicine. 2011 Oct;72(10):559–64.
10. Snezhkina AV, Lukyanova EN, Kalinin DV, Pokrovsky AV, Dmitriev AA, Koroban NV, et al. Exome analysis of carotid body tumor. BMC Medical Genomics. 2018 Feb;11(S1).
11. Bakshi SS, Kumar T L. Carotid Body Tumor. Journal of Pediatric Hematology/Oncology. 2018 Mar;40(2):143–4.
12. Darouassi Y, Alaoui M, Mliha Touati M, AL Maghraoui O, En-nouali A, Bouaity B, et al. Carotid Body Tumors: A Case Series and Review of the Literature. Annals of Vascular Surgery. 2017 Aug;43:265–71.
13. Butt N, Baek WK, Lachkar S, Iwanaga J, Mian A, Blaak C, et al. The carotid body and associated tumors: updated review with clinical/surgical significance. British Journal of Neurosurgery. 2019 May 27;33(5):500–3.
14. Rubio Maicas C, Dualde Beltrán D, Ferrández Izquierdo A, Nersesyan N. Paraganglioma carotídeo maligno. A propósito de un caso. Radiología. 2019 Mar;61(2):171–6.
15. Nishijima H, Asakage T, Sugasawa M. Malignant Carotid Body Tumor with Systemic Metastases. Annals of Otology, Rhinology & Laryngology. 2011 Jun;120(6):381–5.
16. Berger G, Łukasiewicz A, Grinievych V, Tarasów E. Carotid Body Tumor – radiological imaging and genetic assessment. Polish Journal of Surgery. 2020 Nov 6;92(6):39–44
17. Sevil FC. Management and outcomes of vascular reconstruction in carotid body tumor resection: retrospective analysis of 60 cases. European Archives of Oto-Rhino-Laryngology. 2020 Apr 25;277(8):2299–306.
18. Ifeoluwa A, Lázár I, Szövördi É, Karosi T. Management of carotid body tumor in pediatric patients: A case report and review of the literature. International Journal of Pediatric Otorhinolaryngology. 2017 Feb;93:47–52.
19. Del Guercio L, Narese D, Ferrara D, Butrico L, Padricelli A, Porcellini M. Carotid and vagal body paragangliomas. Transl Med UniSa. 2013 May 6;6:11-5.
20. Lee MK, Sidell DR, Mendelsohn AH, Blackwell KE. Hypoglossal Schwannoma Masquerading as a Carotid Body Tumor. Case Reports in Otolaryngology. 2012;2012:1–4.
21. Shamblin WR, ReMine WH, Sheps SG, Jr EGH. Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases. Am J Surg. 1971 Dec;122(6):732-9. doi: 10.1016/0002-9610(71)90436-3.
22. Wreesmann VB, Nixon IJ. A novel classification of carotid body tumors. European Journal of Surgical Oncology. 2021 Aug;47(8):1813–5.
23. Hamming JF, Schepers A. Assessing the complexity of a carotid body tumor resection. European Journal of Surgical Oncology. 2021 Aug;47(8):1811–2.
24. Dorobisz K, Dorobisz T, Temporale H, Zatonski T, Kubacka M, Chabowski M, et al. Diagnostic and Therapeutic Difficulties in Carotid Body Paragangliomas, Based on Clinical Experience and a Review of the Literature. Advances in Clinical and Experimental Medicine. 2016 Dec 19;25(6):1173–7.
25. Liu J, Mu H, Zhang W. Diagnosis and treatment of carotid body tumors. American journal of translational research. 2021 Dec 15;13(12):14121–32.
26. Metheetrairut C, Chotikavanich C, Keskool P, Suphaphongs N. Carotid body tumor: a 25-year experience. European Archives of Oto-Rhino-Laryngology. 2015 Aug 2;273(8):2171–9.
27. Cobb AN, Barkat A, Daungjaiboon W, Halandras P, Crisostomo P, Kuo PC, et al. Carotid Body Tumor Resection: Just as Safe without Preoperative Embolization. Annals of Vascular Surgery. 2020 Apr;64:163–8.
28. Bensaid B, Khalil J, Ould Salek E, El Khaloufi S, Elidrissi R, Lekehal B, et al. A Rare Case of a Massive Carotid Body Tumor in a 3-Year-Old Infant: Case Presentation and a Literature Review. Annals of Vascular Surgery. 2015 Nov;29(8):1661.e9-1661.e15.
29. Xing J, Cheng Y, Ying H, Guan M, Jia N, Bai C. Systemic treatment of a metastatic carotid body tumor. Medicine. 2020 Nov 20;99(47):e22811.
30. Gür AK. Complications associated with carotid body tumor excision. The Turkish Journal of Thoracic and Cardiovascular Surgery. 2018 Jan 31;26(1):81–5.
31. Sevil FC, Tort M, Kaygin MA. Carotid Body Tumor Resection: Long-Term Outcome of 67 Cases without Preoperative Embolization. Annals of Vascular Surgery. 2020 Aug; 67:200–207.