Posterior fossal tuberculoma: an unusual presentation of extrapulmonary tuberculosis

Main Article Content

Carlos Avilez-Soto https://orcid.org/0000-0003-4226-0516
Byron Josué Degrandes Rodríguez https://orcid.org/0000-0003-0257-7551

Keywords

mycobacterium tuberculosis, tuberculoma

Abstract

A tuberculoma is a conglomerate of foci of caseous necrosis in the brain parenchyma produced by hematogenous dissemination. Tuberculosis of the central nervous system has an incidence of 0.06 per million inhabitants, corresponding to 1% of all cases of tuberculosis and 6-10% of extrapulmonary forms in immunocompetent patients. We present the case of a 57-year-old patient with headache of 48 hours of evolution, holocranial, prosopagnosia and psychomotor agitation with tendency to violence. At the same time, he reported unquantified fever, predominantly at night, with the same evolution. CBC with normal findings, serology: HBV, HCV, HIV negative. Chest X-ray showed pleural thickening. CT and MRI showed lesion with ring enhancement pattern in cerebellum. Lumbar puncture was performed reporting: protein: 456mg/dL, glucose: 10mg/dL, cells: 105mm3, mononuclear: 100%, ADA: 23.84U/L, GeneXpert: positive. Antipyretic treatment and steroids were given. Patient evolved satisfactorily.

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References

1. MacNeil A, Glaziou P, Sismanidis C, Maloney S, Floyd K. Global Epidemiology of Tuberculosis and Progress Toward Achieving Global Targets. MMWR Morb Mortal Wkly Rep. [Internet] 2017. [citado 3 Noviembre 2022]: 68(11): 263-66. DOI: 10.15585/mmwr.mm6811a3

2. Pride T, Anyangwe I, Wandji A, Thumano B, Meriki H, Mbacham W. Bacteriologically confirmed extra pulmonary tuberculosis and treatment outcome of patients consulted and treated under program conditions in the littoral region of Cameroo. BMC Pulmonary Medicine. [Internet] 2019. [citado 3 Noviembre 2022]: 19(17): 2-7. DOI: https://doi.org/10.1186/s12890-018-0770-x

3. Bessolo E, Villate E, Arroyo J, Rango G, Ortiz G. Tuberculoma cerebral en placa. Presentación atípica de tuberculosis en el sistema nervioso central. Neurología Argentina. [Internet] 2017. [citado el 11 octubre 2022]: 9(3): 195-98. DOI: 10.1016/j.neuarg.2016.08.003

4. Alharbi A, Khairy S, Sufiani F, Alkhani A. Intracranial tuberculomas: A case report of clinical, radiological, and pathological characteristics. Int J Surg Case Report. [Internet] 2021. [citado el 11 octubre 2022]: 88: 106477. DOI: 10.1016/j.ijscr.2021.106477

5. González G, Birceño G, Gómez M, Martínez Y, Pereira A. Tuberculoma cerebral en paciente pediátrico, descripción diagnostica. Revista Venezolana de Oncología. [Internet] 2019. [citado el 11 octubre 2022]: 31(2): 120-25. Disponible en:
https://www.redalyc.org/journal/3756/375658206006/html/

6. Kamble R, Peruvumba J, Shivashankar R. CT Perfusion Dynamics of Intracranial Tuberculomas. J Clin Diagn Res. [Internet] 2015. [citado el 11 octubre 2022]: 9(5): TC01-5. DOI: 10.7860/JCDR/2015/11587.5880
7. Hernández A, Herrera P, Orellana F, Aponte L, Martinez C, Muñoz R, et al. Tuberculoma cerebral como única manifestación de tuberculosis en embarazada, presentación de un caso. Rev Chil Nuerocirugía. [Internet] 2020. [citado el 11 octubre 2022]: 46: 48-52. DOI: https://doi.org/10.36593/rev.chil.neurocir.v46i1.186

8. Márquez B, López D, Presas J, Font D. Tuberculoma. SEMERGEN. [Internet] 2016. [citado el 11 octubre 2022]: 42(2): 138-39. DOI: 10.1016/j.semerg.2015.03.001

9. Loddenkemper R, Lipman M, Zumla A. Clinical Aspects of Adult Tuberculosis. Cold Springs Harb Perspect Med. [Internet] 2016. [citado el 11 octubre 2022]: 6(1): a017848. DOI: 10.1101/cshperspect.a017848

10. Pereira N, Shah I, Biyani N, Shah F. Frontal lobe tuberculoma. Oxf Med Case Reports. [Internet] 2016. [citado el 11 octubre 2022]: 1: 12-4. DOI: 10.1093/omcr/omv074

11. Mohammadian M, Butt S. Symptomatic central nervous system tuberculoma, a case report in the United States and literature review. IDCases. [Internet] 2019. [citado el 11 octubre 2022]: 17: e00582. DOI: 10.1016/j.idcr.2019.e00582

12. Lizarazo J. Aparición paradójica de tuberculomas encefálicos durante el tratamiento de tuberculosis en pacientes inmunocompetentes. Biomédica. [Internet] 2014. [citado el 12 octubre 2022]: 24(1): 34-42. DOI: https://doi.org/10.7705/biomedica.v24iSupp1.1300

13. Gregol B, Berres T, Barreto T, Giacomelli R, Schwingel D, Oleksinki C, et al. Brain Tuberculoma as a Differential Diagnosis of Single Intracranial Lesion: Case Report. Arquivos Brasileiros de Neurocirugía. [Internet] 2020. [citado el 12 octubre 2022]: 39(2): 142-45. DOI: 10.1055/s-0040-1708895

14. Sonmez G, Ozturk E, Sildiroglu H, Kutlu A, Basekim C, Kizilkaya E. MRI findings of intracranial tuberculomas. Clinical Imaging. [Internet] 2007. [citado el 12 octubre 2022]: 32(2): 88-92. DOI: https://doi.org/10.1016/j.clinimag.2007.08.024

15. Pal D, Bhattacharyya A, Husain M, Pradas KN, Pandley CM, Gupta RK. In Vivo Proton MR Spectroscopy Evaluation of Pyogenic Brain Abscesses: A Report of 194 Cases. AJNR. [Internet] 2010. [citado el 12 octubre 2022]: 31(2): 360-66. DOI: https://doi.org/10.3174/ajnr.A1835

16. Steichen O, Martinez L, Broucker T. [Treatment of tuberculous meningitis]. Rev Neurol. [Internet] 2006. [citado el 12 octubre 2022]: 162(5): 581-93. DOI: 10.1016/s0035-3787(06)75052-4

17. Zahrou F, Elallouchi Y, Ghannane H, Benali S, Aniba K. Diagnosis and management of intracranial tuberculomas: about 2 cases and a review of the literature. Pan Afr Med. [Internet] 2019. [citado el 12 octubre 2022]: 11(34): 23. DOI: 10.11604/pamj.2019.34.23.17587

18. Malagon C, Rodriguez R, Gonzalez M, López L. Diagnostic and Neurological Overview of Brain Tuberculomas: A Review of Literature. Cureus. [Internet] 2021. [citado el 12 octubre 2022]: 13(12): e20133. DOI: 10.7759/cureus.20133